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KMID : 0923620210210030024
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Immune Network
2021 Volume.21 No. 3 p.24 ~ p.24
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Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
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Hong Ji-Hwa
Kim Sang-Hoon
Kim Hyun-Gyung
Jang Jun-Ho
Son Ryeo-Gang
Pack Seung-Pil
Park Young-Ho
Kang Phil-Yong
Jeong Kang-Jin
Kim Ji-Su
Choi Han-Byeul
Kim Sun-Uk
Jung Yong-Woo
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Abstract
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Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
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KEYWORD
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IL-7, Miniature swine, Graft-versus-host disease, T-lymphocytes
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